Generation and characterization of transgenic mice expressing mitochondrial targeted red fluorescent protein selectively in neurons: modeling mitochondriopathy in excitotoxicity and amyotrophic lateral sclerosis
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چکیده
منابع مشابه
Mitochondriopathy in Parkinson disease and amyotrophic lateral sclerosis.
The causes of the selective neurodegeneration in Parkinson disease (PD) and amyotrophic lateral sclerosis (ALS) are unknown and commonalities among these and other age-related neurodegenerative diseases continue to be sought. Morphologic, biochemical, molecular genetic, and cell/animal model studies suggest that mitochondria might be a convergence point for neurodegeneration. The functions and ...
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BACKGROUND The complex neuronal circuitry of the dorsal horn of the spinal cord is as yet poorly understood. However, defining the circuits underlying the transmission of information from primary afferents to higher levels is critical to our understanding of sensory processing. In this study, we have examined phosphodiesterase 1C (Pde1c) BAC transgenic mice in which a green fluorescent protein ...
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Amyotrophic lateral sclerosis (ALS) involves motor neuron degeneration, skeletal muscle atrophy, paralysis, and death. Mutations in Cu,Zn superoxide dismutase (SOD1) are one cause of the disease. Mice transgenic for mutated SOD1 develop symptoms and pathology similar to those in human ALS. To understand the disease mechanism, we developed a simple behavioral assay for disease progression in mic...
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Introduction and Clinical Pathology Amyotrophic lateral sclerosis (ALS) is a prototypic, agedependent neurodegenerative disorder. It typically afflicts individuals in middle adult life, leading to paralysis and death within 3 to 5 years (Williams and Windebank, 1991). The disease usually begins asymmetrically and distally in one limb, most commonly the leg, and then appears to spread within the...
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The best scientist is open to experience and begins with romance-the idea that anything is possible. Caspase-12 cleavage and increased oxidative stress during motoneuron degeneration in transgenic mouse model of ALS. XIAP decreases caspase-12 cleavage and calpain activity in spinal cord of ALS transgenic mice.tribution and levels of cathepsinD and cystatins in amyotro-phic lateral sclerosis tra...
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ژورنال
عنوان ژورنال: Molecular Neurodegeneration
سال: 2011
ISSN: 1750-1326
DOI: 10.1186/1750-1326-6-75